— Tom Clark 2022/02/02 10:37

Apparently this port to PC has a bit of slop in it. Search on the web for “Dead Space Mouse Fix” and you should find a solution that helps. The one I got was from here at PC Gaming Wiki. I just followed the instructions. To find where to paste the “dinput8.dll” file you can go to your Steam game library and right-select Dead Space > Manage > Browse Local Files. I put the file in the same folder as the “Dead Space.exe”. This helped with the mouse lag, but I also disable Vsync in the game. Others have suggested it is also helpful to disable it in your Nvidia configuration software. At the time of this writing it looks as below and all you do is under OpenGL settings, uncheck Sync to VBlank. I actually preferred how the game felt with just going into the graphics settings of the Dead Space game itself and turning Vsync off there. You can play with your mouse DPI settings to tune it to your tastes.

Ultimately, I found that I enjoyed the game better using an Xbox Controller.

Also, I configured the game to skip the intro screen and cap the FPS rate at 60fps. Others have suggested capping the framerate helps with mouse lag. I'm not sure, but 60fps is all I ever want (why let your PC work harder than necessary) so I added that as a launch option.